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Leadership Team

Christopher J. Lindsell PhD

Vanderbilt University Medical Center

Christopher Lindsell is a collaborative biostatistician who is a leader in the application of rigorous of biostatistical methods in the acute care environment, and to the intersection between emergency care and public health. He has led data coordinating centers for numerous multi-center clinical trials, including FDA-regulated trials, and for epidemiological studies. He holds patents on risk stratification in septic shock, and he has contributed significantly to a number of NIH-funded networks, including the CTSA. His current focus is on learning health systems, leveraging clinical processes and data systems to enhance learning from pragmatic trials and observational studies, and for designing and implementing dissemination and implementation research.

Leadership Team

Wesley H. Self, MD, MPH

Vanderbilt University Medical Center

Dr. Self is a physician-scientist focusing on improving the treatment of patients with infectious diseases and critical illness in the emergency department. His research involves disease entities such as pneumonia, sepsis, influenza, and soft tissue infections. He leads emergency department-based clinical trials, epidemiologic studies, and patient safety initiatives.

Leadership Team

David R Janz, MD, MSc

David R Janz, MD, MSc
Louisiana State University School of Medicine 
Director of Medical Critical Care Services at University Medical Center. I earned my medical degree at the LSU School of Medicine New Orleans followed by completion of an Internal Medicine residency, Pulmonary/Critical Care fellowship and Masters of Science in Clinical Investigation at Vanderbilt University, Nashville, TN. I am board certified in Internal Medicine, Pulmonary Medicine, and Critical Care Medicine.

Leadership Team

Derek W. Russell, MD

University of Alabama at Birmingham Medical Center
Dr. Russell received his initial medical training (MD) at the University of Texas Medical Branch with his internal medicine internship and residency completed at Vanderbilt University. Dr. Russell began a clinical and research fellowship in pulmonary and critical care medicine at UAB in 2014. Following his fellowship, he joined the UAB faculty in July 2017. His research and clinical interests relate to the role of neutrophils and extracellular vesicles in pulmonary diseases characterized by neutrophilic inflammation and parenchymal damage such as COPD and ARDS, as well as pragmatic clinical trials on the management of critically ill patients. Dr. Russell has published and presented work on endotracheal intubation, management of respiratory failure, pragmatic clinical trials in the MICU, neutrophils in COPD, matrikines in COPD, exhaled breath biomarkers in ARDS and extracellular vesicles in neutrophilic inflammation. His ongoing work explores the role of neutrophil-derived exosomes in matrix destruction and lung disease.

Leadership Team

Matthew E Prekker, MD MPH

Matthew E Prekker, MD MPH
Hennepin County Medical Center, Minneapolis, MN 

Through specialization in both Emergency Medicine and Pulmonary & Critical Care Medicine, Dr. Prekker provides acute care for patients in the Emergency Department and Medical ICU as well as maintaining a practice as a pulmonary consultant and clinic physician. He has special expertise in resuscitation from critical illness, including airway management, mechanical ventilation, and extracorporeal membrane oxygenation.

Leadership Team

Stacy Trent, MD

Stacy Trent, MD
Emergency Physician, Denver Health Medical Center, Denver, USA

Stacy A. Trent, MD, MPH is an emergency physician and Associate Director of Research in the Department of Emergency Medicine at Denver Health Medical Center.  Dr. Trent’s is a federally-funded researcher whose work focuses on examining and mitigating variation in evidence-based care for airway management, sepsis, and acute coronary syndrome.  Dr. Trent is a member of the executive committee for the Pragmatic Critical Care Research Group, is member of the NHLBI PETAL network serving as a site investigator for the CLOVERS study and is also a member of the NIH SIREN network. 

Twitter:  @drstrent

Leadership Team

Jonathan D. Casey, MD, MSc

Director of the Coordinating Center: Jonathan D. Casey, MD, MSc – Vanderbilt University Medical Center

Jonathan D. Casey MD, MSc is an Assistant Professor of Medicine in the Division of Allergy, Pulmonary, and Critical Care Medicine at Vanderbilt University and a critical care physician in the Medical Intensive Care Unit at Vanderbilt University. Dr. Casey’s work focuses on embedding pragmatic comparative effectiveness trials of standard-of-care interventions into routine care in the emergency department and intensive care unit.  His work aims to answer long-standing questions in airway management, post-extubation respiratory support, extracorporeal membrane oxygenation, and COVID-19.  These efforts have resulted in multiple practice-changing trials published in the New England Journal of Medicine, the Journal of the American Medical Association, and the American Journal of Respiratory and Critical Care Medicine.  Dr. Casey serves as Chair of the Coordinating Center for the Pragmatic Critical Care Research Group and as a member of the NHLBI-funded PETAL Network and the CDC-funded IVY network.

Twitter:  @JonathanCaseyMD

Leadership Team

Matthew W. Semler, MD, MSc

Chair of the Steering Committee: Matthew W. Semler, MD, MSc – Vanderbilt University Medical Center

Matthew W. Semler MD, MSc is an Assistant Professor of Medicine and Biomedical Informatics in the Division of Allergy, Pulmonary, and Critical Care Medicine at Vanderbilt University. Dr. Semler is a critical care physician and Associate Director of the Medical Intensive Care Unit at Vanderbilt University. Dr. Semler’s federally-funded research identifies non-patient-centered variation in current clinical practice, embeds pragmatic randomized trials into clinical care to understand which treatments produce the best outcomes for which patients, and implements the results into practice. Randomized trials he has helped lead, including six published in the New England Journal of Medicine or JAMA, have challenged longstanding dogma around common practices in fluid management, airway management, and respiratory support. Dr. Semler serves as Chair of the Steering Committee for the Pragmatic Critical Care Research Group, co-director of the Inpatient Division of the Learning Healthcare System at Vanderbilt University, and a member of the protocol committee for trials within the NHLBI PETAL Network.