The Pragmatic Critical Care Research Group (PCCRG) is a network of emergency medicine, anesthesiology, and critical care clinicians and researchers at more than 25 hospitals across the United States that embeds pragmatic trials within clinical care to improve outcomes for acutely ill patients.

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Clinical Advisor: Etomidate Reduces Cardiovascular Risks vs Ketamine During Emergency Intubation

Dec 2025

Outlet: Clinical Advisor 

In critically ill adults undergoing emergency tracheal intubation, etomidate did not increase the risk of in-hospital death and resulted in fewer episodes of cardiovascular collapse compared with ketamine, according to findings published in the New England Journal of Medicine. Cardiovascular collapse is a peri-procedural outcome defined as severe hypotension, new or increased vasopressors, cardiac arrest, or death. The occurrence of cardiovascular collapse during tracheal intubation of critically ill adults increases patients’ risk of in-hospital mortality.

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