The Pragmatic Critical Care Research Group (PCCRG) is a network of emergency medicine, anesthesiology, and critical care clinicians and researchers at more than 25 hospitals across the United States that embeds pragmatic trials within clinical care to improve outcomes for acutely ill patients.

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St. Emlyn’s Emergency Medicine blog : Ketamine vs Etomidate for Intubating Critically Ill Adults: What Does the RSI Trial Tell Us?

Jan 2026

outlet: St. Emlyn’s Emergency Medicine blog 

For as long as I can remember, emergency and critical care clinicians have debated the optimal induction agent for tracheal intubation in the critically ill. When I started my anaesthetic placements, I used only two drugs for an RSI, Thiopentone and Suxamethonium. Anything else was considered ‘fancy’ amongst the older anaesthetists. The cool kids were using Etomidate/Sux as an alternative, and as I wanted to move with the times, that became my go-to regimen for many years. That changed when Ketamine became the standard here in Virchester, and these days it’s rare that I use anything else, to be honest. I even still occasionally use Etomidate in selected cases (mostly cardioversions), but the logic behind that is not clear (even to me).

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